DAT1 as a Candidate Gene
DAT1
- VNTR (variable numbers of tandem repeats) of a 40 base-pair repeat sequence on chromosome 15.3
- Majority; 10 repeats or 9 repeats
DAT1 and ADHD
- Dopamine hypothesis; children with ADHD responds well to dopamine agonists and has inhibitory effects on the dopamine transporter (DAT1)
- Animal studies
1) overexpresesion of mutant rat dopamine transporter
2) mucous ‘knockout’ studies

Young Shin Kim